I first need to say that my english is bad so excuse me if I make any mistake in this document.
This tutorial was made because I spent over 4 years using FL Studio 20 on Linux so I might be able to answer your questions or fix your issues.
Disclaimer : FL Studio DOES run well on Linux but works a lot better on Windows (for plugins compatibility and performance)
I always used Ubuntu (Ubuntu 18.04 and Ubuntu 20.04 only) and FL Studio was working the same way.
My PC config : Intel core i3 - 16 Go RAM - GTX 1050ti (for real 60 fps experience lol)
The first thing you have to do obviously is to install Wine.
I recommend you to install the latest stagging version
Here are some issues that you can face when opening FL Studio for the first time.